by Sayeed Ikramuddin, MD; Daniel Leslie, MD; Bryan A. Whitson, MD; and Todd A. Kellogg, MD, PhD

All from the University of Minnesota Medical Center in Minneapolis, Minnesota.

This article serves as an update of an article on the same topic published in Bariatric Times in September, 2005. (Ikramuddin S, Kellogg, TA. Energy Metabolism and Biochemistry of Obesity. Bariatric Times 2005;(2)5:37–9)

Introduction

Obesity, though clearly a result of energy excess in comparison to energy expenditure, has been difficult to establish as a disease. It is true that obesity is now occurring at epidemic proportions. In parallel, efforts to treat obesity are increasing. Currently, surgery is the only proven treatment resulting in sustained weight loss for the morbidly obese.[1] It is important to stress that surgery alone is not effective; however, surgery in a program of behavioral modification and sustained caloric reduction results in sustained weight loss greater than five years.

Read the rest of this article »