Research Bites—May 2010

| May 19, 2010

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Study of the Physiology of the Asthma of the Obese Subjects. BOA Study (Breathing Obesity Asthma)

Purpose: In this observational study, breathing variability will be studied in women using polygraphy (an investigation that is made to detect nocturnal apneas), and airway reactivity will be studied between pulmonary function tests that are made before bariatric surgery. The aim of this study is to evaluate the following:
1.    The variability of the subjects’ diurnal ventilation—based on the measurement of coefficient of variation of tidal volume (CVTV) and frequency of deep inhalations (FDI)—in three groups of women: obese with airway hyperresponsiveness (AHR), obese without AHR and healthy nonobese (main objective)
2.    Whether obesity-related asthma pathophysiology is linked to atopy
3.    Whether obese asthmatic women have a greater decrease in ventilation variability as compared to nonasthmatic obese women (secondary objectives).

Sponsor: Assistance Publique Hôpitaux de Paris

Information provided by: Assistance Publique Hôpitaux de Paris Identifier: NCT00577733

Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes

Purpose: Quercetin is a compound naturally found in various foods. It may have some role in the treatment of obesity and diabetes.The purpose of this study is to investigate research volunteers with obesity or obesity with type 2 diabetes to determine whether quercetin affects the way glucose is absorbed by the body.

Thirty-two participants aged 19 to 65 who are considered to be medically obese or obese with type 2 diabetes will be enrolled in this study. Before the onset of treatment, they will undergo a medical history, physical exam, blood work, and urinalysis. During the study, participants will be given an oral glucose tolerance test three times; during these tests they will receive 1 or 2 grams of quercetin or placebo. Researchers will collect blood samples and analyze the effect of the treatment on blood glucose.

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by: National Institutes of Health Clinical Center (CC) Identifier: NCT00065676

Re-Energize With Nutrition, Exercise, and Weight Loss (RENEW)

Purpose: The purpose of this project is to establish a Center of Excellence in Research on Obesity that will focus on severe obesity. The prevalence of severe obesity (i.e., Class 2 and 3 obesity; body mass index >35kg/m2 and 40kg/m2) is increasing more rapidly than is overweight and Class 1 obesity. Treatment guidelines for severe obesity are uncertain.
The following three novel hypotheses regarding the pathogenesis of severe obesity will be tested:
1.    Using noninvasive methods to measure energy expenditure
2.    Conducting an annotated lipomic search for bio-markers of impaired fat oxidation
3.    Examining the role of obesity-induced inflammation as a cause for leptin resistance.
Responses will also be measured following intervention with diet and activity.

Sponsor: University of Pittsburgh

Collaborator: University of Pennsylvania
Information provided by: University of Pittsburgh Identifier: NCT00712127


Category: Past Articles, Research Bites

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